We convened a session with three leading academics who study the mechanisms of muscle and muscle stem cell aging, a topic that has received a lot of attention recently in the field of muscle biology. Prof. Dongryeol RYU at SKKU, Korea, an expert in aging and metabolism fields who invented the anti-muscle aging medication Urolithin A, whose phase 2 clinical trial was recently completed, will speak about muscle stem cell senescence and a novel therapeutic option. Prof. Young C. JANG, who is an expert in the field of aging and muscle aging at Emory School of Medicine/Georgia Tech, USA, will share his recent progression in skeletal muscle biology and bioengineering. Lastly, Prof. Jinseok LEE from Kyung Hee University, Korea, who is a specialist in the field of artificial intelligence, will share his most recent outcome, a neural network-driven identification of biomarkers predicting patients with sarcopenia. Recently, those syndromes related to muscle aging, such as sarcopenia and frailty, have been assigned a disease classification code, attracting more attention from the science community. In addition, the development of diverse novel research techniques, including single cell transcriptomics, 3D-culture and bioprinting, and artificial neural networks, opens up new avenues toward biomedical advances in the field of the aging in the skeletal system. As three scientists of three distinct hues will introduce and discuss current achievements in muscle and muscle stem cell aging studies undertaken with those novel methodologies, this session will be particularly fascinating for basic and translational biomedical researchers attending the SBHH 2022.

The Symposium 4 was organized to highlight an emerging topic ‘Energy Metabolism in Bone.’ Three leading investigators in the US and Australia have been invited to share the recent updates on their research. Dr. Elizabeth Rendina-Ruedy at the Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA works at the intersection of nutritional biochemistry and bone biology, and her current research focuses on developing a comprehensive understanding of how metabolic pathways impact bone health. Dr. Rendina-Ruedy will share her recent data on the lipid metabolism in the skeletal system. Two renowned Australian investigators, Drs. Hong Zhou at the University of Sydney and Stephen Fitter at the University of Adelaide, will cover the role of glucocorticoid signaling in high-fat diet-induced bone loss and the role of osteoblastic mTORC1 in diet-induced obesity, respectively. The data from these two labs were published in high-profile journals, and the presentation will cover the published and unpublished new data. We hope the audiences will understand the diverse aspects of energy metabolism in bone cells, and how the skeleton is affected by the body’s energy metabolism.