We organized a session with three experts to deal with issues encountered in clinical practice according to the increase in the number of osteoporosis patients and expansion of the choice of treatments. Prof. Sang Min Kim, the first speaker, will talk about the osteoporosis treatment strategy in patients with fractures that occurred during osteoporosis treatment based on research and clinical experience on fragility fractures. The second speaker, Prof. Alexander J. Rodriguez, who has lots of research experience on osteoporosis treatments and cardiovascular safety, will share findings of years of research. Lastly, Prof. Jeonghoon Ha will talk about the comparison of the efficacy of anti-osteoporosis treatments in Asians and non-Asians. While the introduction of Romosozumab raises interest in anabolic agents, there are concerns about cardiovascular complications. This session can be an opportunity to learn and understand the efficacy and safety of osteoporosis treatments, including romosozumab.

We convened a session with three leading academics who study the mechanisms of muscle and muscle stem cell aging, a topic that has received a lot of attention recently in the field of muscle biology. Prof. Dongryeol RYU at SKKU, Korea, an expert in aging and metabolism fields who invented the anti-muscle aging medication Urolithin A, whose phase 2 clinical trial was recently completed, will speak about muscle stem cell senescence and a novel therapeutic option. Prof. Young C. JANG, who is an expert in the field of aging and muscle aging at Emory School of Medicine/Georgia Tech, USA, will share his recent progression in skeletal muscle biology and bioengineering. Lastly, Prof. Jinseok LEE from Kyung Hee University, Korea, who is a specialist in the field of artificial intelligence, will share his most recent outcome, a neural network-driven identification of biomarkers predicting patients with sarcopenia. Recently, those syndromes related to muscle aging, such as sarcopenia and frailty, have been assigned a disease classification code, attracting more attention from the science community. In addition, the development of diverse novel research techniques, including single cell transcriptomics, 3D-culture and bioprinting, and artificial neural networks, opens up new avenues toward biomedical advances in the field of the aging in the skeletal system. As three scientists of three distinct hues will introduce and discuss current achievements in muscle and muscle stem cell aging studies undertaken with those novel methodologies, this session will be particularly fascinating for basic and translational biomedical researchers attending the SBHH 2022.

In this session, we will introduce the latest updates in clinical practice of osteoporosis. First, Professor Kyung-Hwa Park, Department of Oncology, Korea Medical University, will introduce you to how to manage bone loss, which is commonly encountered during chemotherapy, based on various clinical experiences. Next, regarding osteonecrosis of jaw, which can be a problem with long-term use of anti-resorptives, the Korean Society for Bone and Mineral Research and the Korean Society for Oral and Maxillofacial Surgery recently published a revised version of the postion statement. In this regard, Professor Jinwoo Kim of Ewha Medical University, who played a major role in the revision work, will tell you in detail. Lastly, with recent technological developments, various methods have been introduced to diagnose osteoporosis. Professor Kyung-Min Kim, Department of Endocrinology and Metabolism, Yonsei University College of Medicine, will introduce various methods that are being tried recently in diagnosing osteoporosis and predicting fractures. We have prepared interesting and fruitful content, so please participate.

The Symposium 4 was organized to highlight an emerging topic ‘Energy Metabolism in Bone.’ Three leading investigators in the US and Australia have been invited to share the recent updates on their research. Dr. Elizabeth Rendina-Ruedy at the Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA works at the intersection of nutritional biochemistry and bone biology, and her current research focuses on developing a comprehensive understanding of how metabolic pathways impact bone health. Dr. Rendina-Ruedy will share her recent data on the lipid metabolism in the skeletal system. Two renowned Australian investigators, Drs. Hong Zhou at the University of Sydney and Stephen Fitter at the University of Adelaide, will cover the role of glucocorticoid signaling in high-fat diet-induced bone loss and the role of osteoblastic mTORC1 in diet-induced obesity, respectively. The data from these two labs were published in high-profile journals, and the presentation will cover the published and unpublished new data. We hope the audiences will understand the diverse aspects of energy metabolism in bone cells, and how the skeleton is affected by the body’s energy metabolism.